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Precio
687.5€ (96 tests)
Rat Purinergic Receptor P2Y12 (P2RY12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat P2Y purinoceptor 12 concentrations in tissue homogenates, cell lysates and other biological fluids.
P2RY12 is a G protein-coupled receptor activated by ADP, playing a crucial role in platelet aggregation and thrombus formation. P2RY12 couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and enhancing platelet activation and aggregation in response to ADP. It is highly expressed in platelets and some immune cells, where it regulates hemostasis, inflammation, and thrombosis. P2RY12 is a major target for antiplatelet drugs such as clopidogrel, prasugrel, and ticagrelor, which are used to prevent arterial thrombosis, stroke, and myocardial infarction by inhibiting platelet activation. Dysregulation of P2RY12 contributes to thrombotic disorders, while excessive inhibition can lead to bleeding complications. Beyond its role in hemostasis, P2RY12 is involved in immune cell chemotaxis and inflammatory responses. The therapeutic targeting of P2RY12 continues to evolve, particularly for the management of cardiovascular diseases, thrombosis, and inflammation.
ELISA Kits
P2Y Purinoceptor 12 (P2RY12)
Rat
0.312 ng/ml - 20 ng/ml
Sandwich
Quantitative
Colorimetric
Tissue homogenates,Cell lysates,Other biological fluids
96 tests
P2RY12,SP1999,P2YADP,HORK3,P2Y purinoceptor 12,P2Y12 platelet ADP receptor,purinergic receptor P2Y,ADPG-R,BDPLT8,HORK3,P2T(AC),P2Y(12)R,P2Y(AC),P2Y(ADP),P2Y(cyc),P2Y12
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
P2RY12
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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