Human P2Y Purinoceptor 12 (P2RY12) ELISA Kit
643.5€ (96 tests)
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name
Human P2Y Purinoceptor 12 (P2RY12) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx152613
tested applications
ELISA
Description
Human Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Purinergic Receptor P2Y, G Protein Coupled 12 (P2RY12)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | P2Y Purinoceptor 12 (P2RY12) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | P2RY12,SP1999,P2YADP,HORK3,P2Y purinoceptor 12,P2Y12 platelet ADP receptor,purinergic receptor P2Y,ADPG-R,BDPLT8,HORK3,P2T(AC),P2Y(12)R,P2Y(AC),P2Y(ADP),P2Y(cyc),P2Y12 |
| Background | Elisa kits for P2RY12 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
P2RY12 is a G protein-coupled receptor activated by ADP, playing a crucial role in platelet aggregation and thrombus formation. P2RY12 couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and enhancing platelet activation and aggregation in response to ADP. It is highly expressed in platelets and some immune cells, where it regulates hemostasis, inflammation, and thrombosis. P2RY12 is a major target for antiplatelet drugs such as clopidogrel, prasugrel, and ticagrelor, which are used to prevent arterial thrombosis, stroke, and myocardial infarction by inhibiting platelet activation. Dysregulation of P2RY12 contributes to thrombotic disorders, while excessive inhibition can lead to bleeding complications. Beyond its role in hemostasis, P2RY12 is involved in immune cell chemotaxis and inflammatory responses. The therapeutic targeting of P2RY12 continues to evolve, particularly for the management of cardiovascular diseases, thrombosis, and inflammation.
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