P2Y Purinoceptor 12 (P2RY12) Antibody
312€ (50 µl)
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935106861
info@markelab.com
name
P2Y Purinoceptor 12 (P2RY12) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx217587
tested applications
ELISA, WB, IHC
Description
P2RY12 Antibody is a Rabbit Polyclonal against P2RY12.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | P2Y Purinoceptor 12 (P2RY12) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.3, 0.05% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H244 |
| Gene ID | 64805 |
| NCBI Accession | NP_073625 |
| OMIM | 600515 |
| Alias | P2RY12,SP1999,P2YADP,HORK3,P2Y purinoceptor 12,P2Y12 platelet ADP receptor,purinergic receptor P2Y,ADPG-R,BDPLT8,HORK3,P2T(AC),P2Y(12)R,P2Y(AC),P2Y(ADP),P2Y(cyc),P2Y12 |
| Background | Antibody anti-P2RY12 |
| Status | RUO |
Descripción
P2RY12 is a G protein-coupled receptor activated by ADP, playing a crucial role in platelet aggregation and thrombus formation. P2RY12 couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and enhancing platelet activation and aggregation in response to ADP. It is highly expressed in platelets and some immune cells, where it regulates hemostasis, inflammation, and thrombosis. P2RY12 is a major target for antiplatelet drugs such as clopidogrel, prasugrel, and ticagrelor, which are used to prevent arterial thrombosis, stroke, and myocardial infarction by inhibiting platelet activation. Dysregulation of P2RY12 contributes to thrombotic disorders, while excessive inhibition can lead to bleeding complications. Beyond its role in hemostasis, P2RY12 is involved in immune cell chemotaxis and inflammatory responses. The therapeutic targeting of P2RY12 continues to evolve, particularly for the management of cardiovascular diseases, thrombosis, and inflammation.
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