Rat Nociceptin receptor (OPRL1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for OPRL1
proveedor
Abbexareference
abx521329Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Nociceptin receptor (OPRL1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Nociceptin receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
The nociceptin receptor (OPRL1), also known as the opioid receptor-like 1 receptor (ORL1), is a G protein-coupled receptor activated by nociceptin/orphanin FQ, a neuropeptide structurally related to opioid peptides. Unlike classical opioid receptors, OPRL1 does not produce strong analgesic effects when activated. It couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating ion channels to regulate neuronal excitability. OPRL1 is widely expressed in the central nervous system (CNS), particularly in the brainstem, spinal cord, and limbic regions, where it regulates pain modulation, stress responses, anxiety, and reward behaviors. Activation of OPRL1 can produce anti-analgesic effects, opposing classical opioid analgesia, and plays a critical role in preventing opioid-induced tolerance and dependence. Dysregulation of OPRL1 is associated with chronic pain, drug addiction, and mood disorders. OPRL1 agonists and antagonists are being explored for treating addiction, anxiety, and chronic pain without the side effects of traditional opioids.
Características del producto
category
ELISA Kits
immunogen target
Nociceptin receptor (OPRL1)
reactivity
Rat
test range
78 pg/ml - 5000 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
OPRL1,N/OFQ receptor,OP4,KOR-3,NOCIR,kappa3-related opioid receptor,MOR-C,nociceptin receptor ORL1,XOR1,NOP-r,nociceptin/orphanin FQ receptor,NOPr,NOP,OOR,NOPr,OPRL,ORL1,PNOCR
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
OPRL1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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