OPRL1 antibody
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Name
OPRL1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab05997
Tested Applications
ELISA, WB, IHC, IP
Description
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins(G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | opiate receptor-like 1 (OPRL1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 45 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P41146 |
| Gene ID | 4987 |
| Alias | OPRL1,N/OFQ receptor,OP4,KOR-3,NOCIR,kappa3-related opioid receptor,MOR-C,nociceptin receptor ORL1,XOR1,NOP-r,nociceptin/orphanin FQ receptor,NOPr,NOP,OOR,NOPr,OPRL,ORL1,PNOCR |
| Background | Antibody anti-OPRL1 |
| Status | RUO |
| Note | Mol. Weight 45 kDa |
Background
The nociceptin receptor (OPRL1), also known as the opioid receptor-like 1 receptor (ORL1), is a G protein-coupled receptor activated by nociceptin/orphanin FQ, a neuropeptide structurally related to opioid peptides. Unlike classical opioid receptors, OPRL1 does not produce strong analgesic effects when activated. It couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating ion channels to regulate neuronal excitability. OPRL1 is widely expressed in the central nervous system (CNS), particularly in the brainstem, spinal cord, and limbic regions, where it regulates pain modulation, stress responses, anxiety, and reward behaviors. Activation of OPRL1 can produce anti-analgesic effects, opposing classical opioid analgesia, and plays a critical role in preventing opioid-induced tolerance and dependence. Dysregulation of OPRL1 is associated with chronic pain, drug addiction, and mood disorders. OPRL1 agonists and antagonists are being explored for treating addiction, anxiety, and chronic pain without the side effects of traditional opioids.
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