Human OPRL1 (Nociceptin receptor) ELISA Kit
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Name
Human OPRL1 (Nociceptin receptor) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH2512
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 78.125-5000pg/ml |
| Sensitivity | 46.875pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | P41146 |
| Alias | OPRL1,N/OFQ receptor,OP4,KOR-3,NOCIR,kappa3-related opioid receptor,MOR-C,nociceptin receptor ORL1,XOR1,NOP-r,nociceptin/orphanin FQ receptor,NOPr,NOP,OOR,NOPr,OPRL,ORL1,PNOCR |
| Background | Elisa kits for OPRL1 |
| Status | RUO |
Background
The nociceptin receptor (OPRL1), also known as the opioid receptor-like 1 receptor (ORL1), is a G protein-coupled receptor activated by nociceptin/orphanin FQ, a neuropeptide structurally related to opioid peptides. Unlike classical opioid receptors, OPRL1 does not produce strong analgesic effects when activated. It couples to Gi/o proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating ion channels to regulate neuronal excitability. OPRL1 is widely expressed in the central nervous system (CNS), particularly in the brainstem, spinal cord, and limbic regions, where it regulates pain modulation, stress responses, anxiety, and reward behaviors. Activation of OPRL1 can produce anti-analgesic effects, opposing classical opioid analgesia, and plays a critical role in preventing opioid-induced tolerance and dependence. Dysregulation of OPRL1 is associated with chronic pain, drug addiction, and mood disorders. OPRL1 agonists and antagonists are being explored for treating addiction, anxiety, and chronic pain without the side effects of traditional opioids.
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