Rat Insulin Receptor Substrate 2 (IRS2) ELISA Kit

Este producto es parte de IRS -Insulin receptor substrate
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715€ (96 tests)

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935106861
info@markelab.com
name
Rat Insulin Receptor Substrate 2 (IRS2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx155744
tested applications
ELISA

Description

Rat Insulin Receptor Substrate 2 (IRS2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Insulin Receptor Substrate 2 (IRS2) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Insulin Receptor Substrate 2 (IRS2)

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryELISA Kits
Immunogen TargetInsulin Receptor Substrate 2 (IRS2)
ReactivityRat
Detection MethodColorimetric
Assay DataQuantitative
Assay TypeSandwich
Test Range0.78 ng/ml - 50 ng/ml
Sensitivity< 0.33 ng/ml
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
Size 25 × 96 tests
Size 310 × 96 tests
FormLyophilized
Tested ApplicationsELISA
Sample TypeTissue homogenates and other biological fluids.
AvailabilityShipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
StorageShipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
AliasIRS2, IRS-2, insulin receptor substrate 2
BackgroundElisa kits for IRS2
StatusRUO
NoteValidity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

IRS2 is an adaptor protein closely related to IRS1, mediating insulin and IGF signaling through phosphorylation and activation of PI3K/Akt and MAPK pathways. IRS2 is expressed in a broad range of tissues, including the liver, pancreas, and brain, where it regulates glucose metabolism, insulin sensitivity, and cell survival. IRS2 is critical for hepatic insulin signaling, pancreatic β-cell growth, and neuronal function. Dysregulation of IRS2 contributes to metabolic diseases like type 2 diabetes and obesity, as well as neurodegenerative disorders. IRS2-deficient mice exhibit insulin resistance, β-cell dysfunction, and glucose intolerance, emphasizing its role in maintaining systemic glucose homeostasis. IRS2 also plays a role in tumorigenesis, where its overactivation can enhance cell proliferation and survival in cancers like liver and breast cancer.

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