IRS2 (pY978) Antibody

292.5€ (80 µl)
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935106861
info@markelab.com
name
IRS2 (pY978) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032045
tested applications
ELISA, DB
Description
Insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. This protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | IRS2 (pY978) |
Host | Rabbit |
Reactivity | Human |
Assay Data | Modification: Phosphorylation // Target Modification: Tyr978 |
Recommended Dilution | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
Size 1 | 80 µl |
Size 2 | 400 µl |
Form | Liquid |
Tested Applications | ELISA, DB |
Buffer | PBS containing 0.09% sodium azide. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q9Y4H2 |
Alias | IRS2, IRS-2, insulin receptor substrate 2 |
Background | Antibody anti-IRS2 |
Status | RUO |
Descripción
IRS2 is an adaptor protein closely related to IRS1, mediating insulin and IGF signaling through phosphorylation and activation of PI3K/Akt and MAPK pathways. IRS2 is expressed in a broad range of tissues, including the liver, pancreas, and brain, where it regulates glucose metabolism, insulin sensitivity, and cell survival. IRS2 is critical for hepatic insulin signaling, pancreatic β-cell growth, and neuronal function. Dysregulation of IRS2 contributes to metabolic diseases like type 2 diabetes and obesity, as well as neurodegenerative disorders. IRS2-deficient mice exhibit insulin resistance, β-cell dysfunction, and glucose intolerance, emphasizing its role in maintaining systemic glucose homeostasis. IRS2 also plays a role in tumorigenesis, where its overactivation can enhance cell proliferation and survival in cancers like liver and breast cancer.
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