IRS2 (pY978) Antibody

Este producto es parte de IRS -Insulin receptor substrate
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292.5€ (80 µl)

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935106861
info@markelab.com
name
IRS2 (pY978) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032045
tested applications
ELISA, DB

Description

Insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. This protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetIRS2 (pY978)
HostRabbit
ReactivityHuman
Assay DataModification: Phosphorylation // Target Modification: Tyr978
Recommended DilutionDB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Size 180 µl
Size 2400 µl
FormLiquid
Tested ApplicationsELISA, DB
BufferPBS containing 0.09% sodium azide.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDQ9Y4H2
AliasIRS2, IRS-2, insulin receptor substrate 2
BackgroundAntibody anti-IRS2
StatusRUO

Descripción

IRS2 is an adaptor protein closely related to IRS1, mediating insulin and IGF signaling through phosphorylation and activation of PI3K/Akt and MAPK pathways. IRS2 is expressed in a broad range of tissues, including the liver, pancreas, and brain, where it regulates glucose metabolism, insulin sensitivity, and cell survival. IRS2 is critical for hepatic insulin signaling, pancreatic β-cell growth, and neuronal function. Dysregulation of IRS2 contributes to metabolic diseases like type 2 diabetes and obesity, as well as neurodegenerative disorders. IRS2-deficient mice exhibit insulin resistance, β-cell dysfunction, and glucose intolerance, emphasizing its role in maintaining systemic glucose homeostasis. IRS2 also plays a role in tumorigenesis, where its overactivation can enhance cell proliferation and survival in cancers like liver and breast cancer.

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