IRS2 (pY978) Antibody
292.5€ (80 µl)
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935106861
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name
IRS2 (pY978) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032045
tested applications
ELISA, DB
Description
Insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. This protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | IRS2 (pY978) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr978 |
| Recommended Dilution | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, DB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y4H2 |
| Alias | IRS2, IRS-2, insulin receptor substrate 2 |
| Background | Antibody anti-IRS2 |
| Status | RUO |
Descripción
IRS2 is an adaptor protein closely related to IRS1, mediating insulin and IGF signaling through phosphorylation and activation of PI3K/Akt and MAPK pathways. IRS2 is expressed in a broad range of tissues, including the liver, pancreas, and brain, where it regulates glucose metabolism, insulin sensitivity, and cell survival. IRS2 is critical for hepatic insulin signaling, pancreatic β-cell growth, and neuronal function. Dysregulation of IRS2 contributes to metabolic diseases like type 2 diabetes and obesity, as well as neurodegenerative disorders. IRS2-deficient mice exhibit insulin resistance, β-cell dysfunction, and glucose intolerance, emphasizing its role in maintaining systemic glucose homeostasis. IRS2 also plays a role in tumorigenesis, where its overactivation can enhance cell proliferation and survival in cancers like liver and breast cancer.
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This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
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