Insulin Receptor Substrate 2 (IRS2) Antibody
312€ (60 µl)
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935106861
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name
Insulin Receptor Substrate 2 (IRS2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006046
tested applications
WB, IF/ICC
Description
IRS2 Antibody is a Rabbit Polyclonal Antibody against IRS2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Insulin Receptor Substrate 2 (IRS2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y4H2 |
| Gene ID | 8660 |
| NCBI Accession | NP_003740.2 |
| Alias | IRS2, IRS-2, insulin receptor substrate 2 |
| Background | Antibody anti-IRS2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
IRS2 is an adaptor protein closely related to IRS1, mediating insulin and IGF signaling through phosphorylation and activation of PI3K/Akt and MAPK pathways. IRS2 is expressed in a broad range of tissues, including the liver, pancreas, and brain, where it regulates glucose metabolism, insulin sensitivity, and cell survival. IRS2 is critical for hepatic insulin signaling, pancreatic β-cell growth, and neuronal function. Dysregulation of IRS2 contributes to metabolic diseases like type 2 diabetes and obesity, as well as neurodegenerative disorders. IRS2-deficient mice exhibit insulin resistance, β-cell dysfunction, and glucose intolerance, emphasizing its role in maintaining systemic glucose homeostasis. IRS2 also plays a role in tumorigenesis, where its overactivation can enhance cell proliferation and survival in cancers like liver and breast cancer.
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