Rat A Kinase Anchor Protein 11 (AKAP11) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat A Kinase Anchor Protein 11 (AKAP11) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501386
tested applications
ELISA
Description
Rat A Kinase Anchor Protein 11 (AKAP11) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat A-kinase anchor protein 11 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A Kinase Anchor Protein 11 (AKAP11) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q62924 |
| Alias | AKAP-11,AKAP220,PPP1R44,PRKA11 |
| Background | Elisa kits for AKAP11 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP11, also referred to as AKAP220, is a large cytosolic scaffold protein that binds PKA, phosphodiesterase-4D (PDE4D), and other signaling enzymes, coordinating cAMP and PKA signaling pathways in diverse cellular contexts. AKAP11 is highly expressed in neurons and spermatozoa, where it regulates PKA-dependent signaling for processes like synaptic plasticity, sperm motility, and energy metabolism. AKAP11 forms complexes with PDE4D, ensuring spatial and temporal regulation of cAMP levels, which is critical for cell signaling specificity. Dysregulation of AKAP11 has been linked to infertility, as its loss impairs sperm flagellar movement and mitochondrial ATP production. In neurons, AKAP11 modulates cAMP signaling involved in synaptic transmission, learning, and memory. Studies have also identified AKAP11 as a target in cancer biology, where its misregulation influences cell proliferation, migration, and anchoring of signaling components that regulate growth pathways like MAPK and AMPK.
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