Human A Kinase Anchor Protein 11 (AKAP11) Protein
234€ (10 µg)
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935106861
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name
Human A Kinase Anchor Protein 11 (AKAP11) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167856
tested applications
WB, SDS-PAGE
Description
A Kinase Anchor Protein 11 is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | A Kinase Anchor Protein 11 (AKAP11) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 31.4 kDa Observed MW (SDS-PAGE): 36 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu1650-Ala1901 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AKAP-11,AKAP220,PPP1R44,PRKA11 |
| Background | Protein AKAP11 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AKAP11, also referred to as AKAP220, is a large cytosolic scaffold protein that binds PKA, phosphodiesterase-4D (PDE4D), and other signaling enzymes, coordinating cAMP and PKA signaling pathways in diverse cellular contexts. AKAP11 is highly expressed in neurons and spermatozoa, where it regulates PKA-dependent signaling for processes like synaptic plasticity, sperm motility, and energy metabolism. AKAP11 forms complexes with PDE4D, ensuring spatial and temporal regulation of cAMP levels, which is critical for cell signaling specificity. Dysregulation of AKAP11 has been linked to infertility, as its loss impairs sperm flagellar movement and mitochondrial ATP production. In neurons, AKAP11 modulates cAMP signaling involved in synaptic transmission, learning, and memory. Studies have also identified AKAP11 as a target in cancer biology, where its misregulation influences cell proliferation, migration, and anchoring of signaling components that regulate growth pathways like MAPK and AMPK.
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