Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Antibody
Pida mas información
935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-PTPRA
proveedor
Abbexareference
abx001610Tested Applications
ELISA, WB, IHCreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
PTPRA Antibody is a Rabbit Polyclonal antibody against PTPRA. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.
Background
PTPRA is a receptor-like protein tyrosine phosphatase involved in dephosphorylating tyrosine residues in target proteins to regulate cellular signaling pathways. Structurally, it has an extracellular domain, a transmembrane region, and two intracellular phosphatase domains, with the first domain being enzymatically active. PTPRA is expressed ubiquitously, with high levels in brain and muscle tissues. It activates Src family kinases by dephosphorylating inhibitory phosphotyrosines, influencing cell proliferation, adhesion, and migration. PTPRA plays significant roles in neuronal signaling, integrin-mediated cell adhesion, and oncogenic processes. Dysregulation is associated with cancers and neurological disorders.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Protein Tyrosine Phosphatase Receptor Type A (PTPRA)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000, IHC-P: 1/100 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
PTPRA
dry ice
No
availability
Shipped within 5-10 working days.
alias
LRP,HLPR,PTPA,HEPTP,HPTPA,RPTPA,PTPRL2,HPTPalpha,R-PTP-alpha,Protein-tyrosine phosphatase alpha,Receptor-type tyrosine-protein phosphatase alpha
uniprot id
NCBI accession
NP_543031.1
note
Concentration: > 0.2 mg/ml -
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