Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Antibody
195€ (20 µl)
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Name
Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx126438
Tested Applications
ELISA, WB
Description
PTPRA Antibody is a Rabbit Polyclonal against PTPRA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein Tyrosine Phosphatase Receptor Type A (PTPRA) Immunogen: Recombinant protein corresponding to PTPRA. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 91 kDa Observed MW: 145 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P18433 |
| Gene ID | 5786 |
| NCBI Accession | NP_543030.1 |
| Alias | LRP,HLPR,PTPA,HEPTP,HPTPA,RPTPA,PTPRL2,HPTPalpha,R-PTP-alpha,Protein-tyrosine phosphatase alpha,Receptor-type tyrosine-protein phosphatase alpha |
| Background | Antibody anti-PTPRA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTPRA is a receptor-like protein tyrosine phosphatase involved in dephosphorylating tyrosine residues in target proteins to regulate cellular signaling pathways. Structurally, it has an extracellular domain, a transmembrane region, and two intracellular phosphatase domains, with the first domain being enzymatically active. PTPRA is expressed ubiquitously, with high levels in brain and muscle tissues. It activates Src family kinases by dephosphorylating inhibitory phosphotyrosines, influencing cell proliferation, adhesion, and migration. PTPRA plays significant roles in neuronal signaling, integrin-mediated cell adhesion, and oncogenic processes. Dysregulation is associated with cancers and neurological disorders.
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