anti- PTPRA antibody

Name: anti- PTPRA antibody
Brand: FineTest
SKU: FNab06942
Availability: OnlineOnly

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-PTPRA

proveedor

FineTest

reference

FNab06942

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Background

PTPRA is a receptor-like protein tyrosine phosphatase involved in dephosphorylating tyrosine residues in target proteins to regulate cellular signaling pathways. Structurally, it has an extracellular domain, a transmembrane region, and two intracellular phosphatase domains, with the first domain being enzymatically active. PTPRA is expressed ubiquitously, with high levels in brain and muscle tissues. It activates Src family kinases by dephosphorylating inhibitory phosphotyrosines, influencing cell proliferation, adhesion, and migration. PTPRA plays significant roles in neuronal signaling, integrin-mediated cell adhesion, and oncogenic processes. Dysregulation is associated with cancers and neurological disorders.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

protein tyrosine phosphatase, receptor type, A

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC

observerd MW

70 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

or code

PTPRA

alias

LRP,HLPR,PTPA,HEPTP,HPTPA,RPTPA,PTPRL2,HPTPalpha,R-PTP-alpha,Protein-tyrosine phosphatase alpha,Receptor-type tyrosine-protein phosphatase alpha

uniprot id

https://www.uniprot.org/uniprotkb/P18433

gene id

https://www.ncbi.nlm.nih.gov/gene/5786

note

This product is for research use only.

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