Prostate And Breast Cancer Overexpressed 1 (PBOV1) Antibody

Background

Prostate And Breast Cancer Overexpressed 1 (PBOV1), also known as UROC28, is a gene prominently overexpressed in prostate, breast, and bladder cancers, where it is thought to play a role in tumor progression and metastasis. While its precise molecular functions remain under investigation, PBOV1 is primarily associated with enhanced cell proliferation, migration, and invasion, contributing to the aggressive behavior of cancer cells. It is localized in the cytoplasm and has been suggested to interact with key signaling pathways involved in tumorigenesis, although its direct binding partners are not yet fully characterized. Its expression is regulated by epigenetic mechanisms, including promoter methylation, and high levels of PBOV1 have been correlated with poor clinical outcomes and shorter survival rates in cancer patients. PBOV1 serves as a potential biomarker for cancer diagnosis and prognosis, with studies indicating its utility in distinguishing malignant tissues from normal or benign counterparts. Efforts are being made to explore PBOV1 as a therapeutic target, as silencing its expression in preclinical models has shown to reduce tumor growth and invasiveness. Its cancer-specific overexpression and limited presence in normal tissues make it a promising candidate for targeted therapies and diagnostic tools in oncology.