PBOV1 - Prostate And Breast Cancer Overexpressed 1 | Elisa - Clia - Antibody - Protein

Background

Prostate And Breast Cancer Overexpressed 1 (PBOV1), also known as UROC28, is a gene that encodes a protein frequently overexpressed in various cancers, notably prostate, breast, and bladder cancers. The PBOV1 gene is located on chromosome 6q23.3. Its expression is low or absent in most normal tissues but significantly elevated in certain cancerous tissues, suggesting its role in tumorigenesis and cancer progression. PBOV1 was initially identified through differential gene expression analysis, aimed at discovering genes with higher expression levels in cancerous tissues compared to normal tissues.

Protein Structure

The exact structure of the PBOV1 protein remains not fully characterized due to limited structural studies. However, based on sequence analysis, it is predicted to be a small, soluble protein without transmembrane domains or significant homology to other known proteins, indicating it may have unique functional properties in cancer cells. The protein consists of:

• Signal Peptide: Directs the nascent protein to the secretory pathway.
• Hydrophilic Regions: Suggests it may be involved in interactions with other intracellular or extracellular proteins rather than embedding in membranes.

Classification and Subtypes

PBOV1 does not belong to a large protein family with numerous subtypes but is rather a unique gene with its specific expression profile. It is often studied in the context of its overexpression in cancer rather than its belonging to a broader class of proteins.

Function and Biological Significance

The biological function of PBOV1 in normal physiology remains unclear, but its role in cancer has been more thoroughly investigated. Key functions and significances include:

• Cell Proliferation: PBOV1 is believed to promote cancer cell proliferation, making it a potential target for therapeutic intervention.
• Invasion and Metastasis: Studies suggest that PBOV1 may contribute to the invasive and metastatic properties of cancer cells, though the precise mechanisms remain under investigation.
• Prognostic Marker: Due to its overexpression in certain cancers, PBOV1 might serve as a biomarker for prognosis, aiding in the prediction of disease outcome and treatment response.

Clinical Issues

• Cancer: Overexpression of PBOV1 has been correlated with the aggressiveness of prostate, breast, and bladder cancers. High levels of PBOV1 are associated with poor prognosis and increased risk of metastasis.
• Diagnostic and Therapeutic Potential: Given its specific overexpression in cancerous tissues, PBOV1 is being explored as a diagnostic marker and a potential therapeutic target. Inhibiting PBOV1 expression or function might slow down tumor growth and spread, providing a new avenue for cancer treatment.

Summary

PBOV1 (Prostate And Breast Cancer Overexpressed 1) is a protein predominantly expressed in certain cancers, with significant implications for tumor proliferation, invasion, and metastasis. While its exact biological function in normal tissues is not fully understood, its overexpression in cancer highlights its potential as a biomarker for prognosis and a target for therapeutic intervention. Understanding PBOV1's role in cancer can lead to better diagnostic and treatment strategies, offering hope for improved patient outcomes in cancers where PBOV1 is overexpressed.