Prostaglandin E Synthase 3 (PTGES3) Antibody
312€ (60 µl)
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Name
Prostaglandin E Synthase 3 (PTGES3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx004071
Tested Applications
IHC
Description
PTGES3 Antibody is a Rabbit Polyclonal antibody against PTGES3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Prostaglandin E Synthase 3 (PTGES3) Immunogen: Recombinant fusion protein corresponding to human PTGES3 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 14 kDa/16 kDa/18 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15185 |
| Gene ID | 10728 |
| NCBI Accession | NP_006592.3 |
| Alias | P23,TEBP,cPGES,Progesterone receptor complex p23,Telomerase-binding protein p23 |
| Background | Antibody anti-PTGES3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Prostaglandin E synthase 3 (PTGES3), also known as p23, is a multifunctional protein that acts as a co-chaperone for heat shock protein 90 (HSP90), playing a crucial role in the stabilization and activity of various client proteins, including steroid hormone receptors and kinases. It catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), a lipid mediator involved in inflammation, immune response, and various physiological processes such as fever, pain, and vascular homeostasis. PTGES3 is also essential for the proper functioning of the glucocorticoid receptor complex, regulating its maturation and nuclear translocation. Dysregulation of PTGES3 expression has been implicated in cancer progression, as it influences tumor growth, angiogenesis, and immune evasion through PGE2-mediated signaling pathways. In addition to its roles in prostaglandin biosynthesis and HSP90 client protein stabilization, PTGES3 has been associated with the regulation of transcriptional activity and cellular stress responses, underscoring its diverse biological functions. Its expression is tightly regulated and can be modulated by cellular stress, hormonal signals, and inflammatory stimuli, highlighting its importance in maintaining cellular homeostasis and responding to external cues.
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