Pro-Gastrin Releasing Peptide (ProGRP) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Pro-Gastrin Releasing Peptide (ProGRP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236798
tested applications
ELISA, WB, IHC
Description
ProGRP Antibody is a Rabbit Polyclonal against ProGRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pro-Gastrin Releasing Peptide (ProGRP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P07492 |
| Gene ID | 2922 |
| Alias | BN,GRP-10,proGRP,preproGRP |
| Background | Antibody anti-ProGRP |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Pro-Gastrin Releasing Peptide (ProGRP) is a precursor protein for gastrin-releasing peptide (GRP), a neuropeptide involved in a variety of physiological processes, including the regulation of gastric acid secretion, smooth muscle contraction, and pancreatic enzyme release. GRP is also known for its role in neural signaling, particularly in the central nervous system, where it modulates stress, memory, and circadian rhythm. ProGRP is a clinically significant biomarker, particularly in the diagnosis and monitoring of small cell lung cancer (SCLC), where elevated levels in serum are associated with disease presence and progression. The stability of ProGRP in circulation makes it a superior biomarker compared to GRP itself, as it provides a more reliable measure for diagnostic purposes. Beyond its use in oncology, ProGRP may play a role in gastrointestinal and neuroendocrine disorders, with its expression linked to cellular proliferation and secretion. Current research focuses on its potential as a therapeutic target in SCLC and other malignancies, as well as its broader role in neuroendocrine signaling pathways.
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