PHD Finger Protein 3 (PHF3) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
PHD Finger Protein 3 (PHF3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014709
tested applications
ELISA, IHC
Description
Rabbit polyclonal antibody against PHF3 protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PHD Finger Protein 3 (PHF3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IHC: 1/50 - 1/100, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92576 |
| Alias | PHF3, KIAA0244 |
| Background | Antibody anti-PHF3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PHF3 is a chromatin-binding protein containing a PHD domain that mediates the recognition of methylated histones, particularly H3K4me3, to regulate transcriptional activation and RNA polymerase II-dependent transcription. It serves as a transcriptional regulator by linking histone modifications to transcription elongation, ensuring precise gene expression during cellular proliferation and differentiation. PHF3 is expressed in neuronal and hematopoietic tissues, where it contributes to neurodevelopment, DNA damage repair, and cell survival. It is also involved in tumor suppression, where it stabilizes chromatin structure and controls the expression of growth-regulating genes. Dysregulation of PHF3 is linked to neurodevelopmental disorders and cancers, where its loss of function disrupts transcriptional regulation and genome stability. Knockout studies reveal defects in transcription elongation, impaired DNA repair, and disrupted cellular differentiation, underscoring its critical role in transcriptional fidelity, chromatin regulation, and cellular homeostasis.
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