Pappalysin 2 (PAPPA2) Antibody
286€ (100 µl)
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935106861
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name
Pappalysin 2 (PAPPA2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx101232
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Pappalysin 2 (PAPPA2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Pappalysin 2 (PAPPA2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BXP8 |
| Alias | PLAC3,Pregnancy-associated plasma protein A2,PAPP-A2,Pregnancy-associated plasma protein E1,PAPP-E |
| Background | Antibody anti-PAPPA2 |
| Status | RUO |
Descripción
PAPPA2, a close homolog of PAPPA, is also a zinc-dependent metalloproteinase that cleaves IGF-binding proteins, specifically IGFBP-5, to regulate the availability of insulin-like growth factors (IGFs). PAPPA2 is involved in controlling skeletal development, bone growth, and tissue regeneration by increasing IGF activity, which promotes cell proliferation and differentiation. It plays an essential role in fetal growth and development, with mutations in PAPPA2 linked to short stature and growth retardation due to reduced IGF bioavailability. PAPPA2 expression is also associated with metabolic disorders, such as insulin resistance and diabetes, and it has been implicated in certain cancers, where dysregulation of IGF signaling contributes to tumor progression. PAPPA2’s function in IGF regulation makes it a critical factor in growth-related processes and a potential target for therapeutic intervention.
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