Human Pappalysin 2 (PAPPA2) Protein
234€ (10 µg)
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name
Human Pappalysin 2 (PAPPA2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx068417
tested applications
WB, SDS-PAGE
Description
Human Pappalysin 2 (PAPPA2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Pappalysin 2 (PAPPA2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 24.4 kDa Observed MW (SDS-PAGE): 27 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly888-Ala1093 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BXP8 |
| Alias | PLAC3,Pregnancy-associated plasma protein A2,PAPP-A2,Pregnancy-associated plasma protein E1,PAPP-E |
| Background | Protein PAPPA2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PAPPA2, a close homolog of PAPPA, is also a zinc-dependent metalloproteinase that cleaves IGF-binding proteins, specifically IGFBP-5, to regulate the availability of insulin-like growth factors (IGFs). PAPPA2 is involved in controlling skeletal development, bone growth, and tissue regeneration by increasing IGF activity, which promotes cell proliferation and differentiation. It plays an essential role in fetal growth and development, with mutations in PAPPA2 linked to short stature and growth retardation due to reduced IGF bioavailability. PAPPA2 expression is also associated with metabolic disorders, such as insulin resistance and diabetes, and it has been implicated in certain cancers, where dysregulation of IGF signaling contributes to tumor progression. PAPPA2’s function in IGF regulation makes it a critical factor in growth-related processes and a potential target for therapeutic intervention.
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Human Pappalysin 2 (PAPPA2) Protein
Human Pappalysin 2 (PAPPA2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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Human Pappalysin 2 (PAPPA2) Protein
Pappalysin 2 (PAPPA2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver Producto