Human Pappalysin 2 (PAPPA2) Protein

Este producto es parte de PAPPA - Pregnancy Associated Plasma Protein /Pappalysin
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234€ (10 µg)

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935106861
info@markelab.com
name
Human Pappalysin 2 (PAPPA2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx068418
tested applications
WB, SDS-PAGE

Description

Human Pappalysin 2 (PAPPA2) is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Pappalysin 2 (PAPPA2)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: His1309-Ser1492
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 21.1 kDa  Observed MW (SDS-PAGE): 23 kDa
Expression
Recombinant
Purity
> 97%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl and 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q9BXP8
Alias
PLAC3,Pregnancy-associated plasma protein A2,PAPP-A2,Pregnancy-associated plasma protein E1,PAPP-E
Background
Protein PAPPA2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

PAPPA2, a close homolog of PAPPA, is also a zinc-dependent metalloproteinase that cleaves IGF-binding proteins, specifically IGFBP-5, to regulate the availability of insulin-like growth factors (IGFs). PAPPA2 is involved in controlling skeletal development, bone growth, and tissue regeneration by increasing IGF activity, which promotes cell proliferation and differentiation. It plays an essential role in fetal growth and development, with mutations in PAPPA2 linked to short stature and growth retardation due to reduced IGF bioavailability. PAPPA2 expression is also associated with metabolic disorders, such as insulin resistance and diabetes, and it has been implicated in certain cancers, where dysregulation of IGF signaling contributes to tumor progression. PAPPA2’s function in IGF regulation makes it a critical factor in growth-related processes and a potential target for therapeutic intervention.

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