Oxysterols Receptor LXR-Beta (NR1H2) Antibody
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Description
NR1H2 Antibody is a Rabbit Polyclonal against NR1H2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Oxysterols Receptor LXR-Beta (NR1H2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P55055 |
| Gene ID | 7376 |
| OMIM | 600380 |
| Alias | NER,UNR,LXRB,LXR-b,NER-I,RIP15,Oxysterols receptor LXR-beta,Liver X receptor beta,Nuclear receptor NER |
| Background | Antibody anti-NR1H2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Nuclear receptor subfamily 1 group H member 2 (NR1H2), also known as LXRα (liver X receptor alpha), is a nuclear receptor involved in regulating lipid metabolism, cholesterol homeostasis, and immune response NR1H2 is primarily expressed in tissues such as the liver, adipose tissue, and macrophages, where it regulates genes involved in the absorption, storage, and catabolism of cholesterol and lipids LXRα plays a key role in maintaining cholesterol balance by promoting the expression of genes that enhance cholesterol efflux and inhibit cholesterol biosynthesis It also regulates inflammatory pathways, influencing the immune system's response to atherosclerosis and other chronic inflammatory diseases Dysregulation of NR1H2 signaling has been associated with cardiovascular diseases, such as atherosclerosis, where improper lipid metabolism leads to the accumulation of cholesterol plaques in blood vessels LXRα is also a potential therapeutic target for managing metabolic diseases, inflammation, and lipid-related disorders
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