Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing(DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
Primary Antibodies
polyclonal
human,mouse,rat
nuclear receptor subfamily 1, group H, member 2
Rabbit
IgG
Unconjugated
liquid
ELISA, WB
50 kDa, 40 kDa
≥95% as determined by SDS-PAGE
Immunogen affinity purified
WB: 1:200-1:2000
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
NR1H2
NER,UNR,LXRB,LXR-b,NER-I,RIP15,Oxysterols receptor LXR-beta,Liver X receptor beta,Nuclear receptor NER
This product is for research use only.
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