Oxysterols Receptor LXR-Beta (NR1H2) Antibody
292.5€ (80 µl)
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Name
Oxysterols Receptor LXR-Beta (NR1H2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx033981
Tested Applications
ELISA, WB
Description
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Oxysterols Receptor LXR-Beta (NR1H2) Immunogen: KLH-conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of human NR1H2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 51 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P55055 |
| Alias | NER,UNR,LXRB,LXR-b,NER-I,RIP15,Oxysterols receptor LXR-beta,Liver X receptor beta,Nuclear receptor NER |
| Background | Antibody anti-NR1H2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nuclear receptor subfamily 1 group H member 2 (NR1H2), also known as LXRα (liver X receptor alpha), is a nuclear receptor involved in regulating lipid metabolism, cholesterol homeostasis, and immune response NR1H2 is primarily expressed in tissues such as the liver, adipose tissue, and macrophages, where it regulates genes involved in the absorption, storage, and catabolism of cholesterol and lipids LXRα plays a key role in maintaining cholesterol balance by promoting the expression of genes that enhance cholesterol efflux and inhibit cholesterol biosynthesis It also regulates inflammatory pathways, influencing the immune system's response to atherosclerosis and other chronic inflammatory diseases Dysregulation of NR1H2 signaling has been associated with cardiovascular diseases, such as atherosclerosis, where improper lipid metabolism leads to the accumulation of cholesterol plaques in blood vessels LXRα is also a potential therapeutic target for managing metabolic diseases, inflammation, and lipid-related disorders
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