Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
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Description
Oxysterols Receptor LXR-Alpha (NR1H3) Antibody is a Rabbit polyclonal antibody for the detection of Human Oxysterols Receptor LXR-Alpha (NR1H3).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Oxysterols Receptor LXR-Alpha (NR1H3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13133 |
| Gene ID | 10062 |
| NCBI Accession | NP_001123573.1 |
| Alias | LXRA,LXR-a,RLD-1,Oxysterols receptor LXR-alpha,Liver X receptor alpha,Nuclear receptor subfamily 1 group H member 3 |
| Background | Antibody anti-NR1H3 |
| Status | RUO |
Descripción
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Human NR1H3 (Oxysterols receptor LXR-alpha) ELISA Kit
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NR1H3 antibody
Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
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Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
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