Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
312€ (60 µl)
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935106861
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name
Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001753
tested applications
WB
Description
NR1H3 Antibody is a Rabbit Polyclonal antibody against NR1H3. The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Oxysterols Receptor LXR-Alpha (NR1H3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13133 |
| Gene ID | 10062 |
| NCBI Accession | NP_005684.2 |
| Alias | LXRA,LXR-a,RLD-1,Oxysterols receptor LXR-alpha,Liver X receptor alpha,Nuclear receptor subfamily 1 group H member 3 |
| Background | Antibody anti-NR1H3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Nuclear receptor subfamily 1 group H member 3 (NR1H3), also known as LXRβ (liver X receptor beta), is another member of the LXR family of nuclear receptors involved in regulating lipid and cholesterol metabolism NR1H3 is highly expressed in tissues like the liver, intestine, and adipose tissue, where it helps regulate the expression of genes that control cholesterol efflux, lipid storage, and glucose metabolism LXRβ also plays a role in regulating the immune system, particularly in macrophages, where it modulates the inflammatory response and contributes to the resolution of inflammation It helps maintain metabolic balance by controlling lipid homeostasis and by influencing glucose metabolism and insulin sensitivity Dysregulation of NR1H3 has been implicated in conditions such as type 2 diabetes, obesity, and cardiovascular diseases, where abnormal lipid metabolism and inflammation contribute to disease progression LXRβ is also a potential drug target for the treatment of atherosclerosis, metabolic disorders, and inflammatory diseases
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Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
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