Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
292.5€ (80 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx034585
Tested Applications
ELISA, WB, IF/ICC, FCM
Description
NR1H3 form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Oxysterols Receptor LXR-Alpha (NR1H3) Immunogen: KLH-conjugated synthetic peptide between 226-253 amino acids from the Central region of human NR1H3. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 50.4 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13133 |
| Alias | LXRA,LXR-a,RLD-1,Oxysterols receptor LXR-alpha,Liver X receptor alpha,Nuclear receptor subfamily 1 group H member 3 |
| Background | Antibody anti-NR1H3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Nuclear receptor subfamily 1 group H member 3 (NR1H3), also known as LXRβ (liver X receptor beta), is another member of the LXR family of nuclear receptors involved in regulating lipid and cholesterol metabolism NR1H3 is highly expressed in tissues like the liver, intestine, and adipose tissue, where it helps regulate the expression of genes that control cholesterol efflux, lipid storage, and glucose metabolism LXRβ also plays a role in regulating the immune system, particularly in macrophages, where it modulates the inflammatory response and contributes to the resolution of inflammation It helps maintain metabolic balance by controlling lipid homeostasis and by influencing glucose metabolism and insulin sensitivity Dysregulation of NR1H3 has been implicated in conditions such as type 2 diabetes, obesity, and cardiovascular diseases, where abnormal lipid metabolism and inflammation contribute to disease progression LXRβ is also a potential drug target for the treatment of atherosclerosis, metabolic disorders, and inflammatory diseases
Productos relacionados
Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
NR1H3 Antibody is a Rabbit Polyclonal antibody against NR1H3. The protein encoded by this gene belongs to the NR1 subfam…
Ver producto Oxysterols Receptor LXR-Alpha (NR1H3) Antibody
NR1H3 form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling tr…
Ver producto
Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) Antibody
Nuclear Receptor Subfamily 1, Group H, Member 3 Antibody is a Rabbit Polyclonal antibody against Nuclear Receptor Subfam…
Ver producto