Neuromedin-B Receptor (NMBR) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Neuromedin-B Receptor (NMBR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx326919
tested applications
WB, IHC
Description
NMBR Antibody is a Rabbit Polyclonal against NMBR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuromedin-B Receptor (NMBR) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000 - 1/2000, IHC: 1/200 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28336 |
| Gene ID | 4829 |
| OMIM | 162341 |
| Alias | NMBR,BB1 receptor,NMB-R BB1,neuromedin B receptor,neuromedin-B-preferring bombesin receptor,BB1R,BRS1 |
| Background | Antibody anti-NMBR |
| Status | RUO |
Descripción
The Neuromedin B receptor (NMBR) is a G-protein-coupled receptor (GPCR) that binds to neuromedin B (NMB), a peptide belonging to the bombesin-like peptide family. NMBR is widely expressed in the central nervous system (CNS), the gastrointestinal tract, and the lungs. In the CNS, NMBR plays a role in thermoregulation, particularly in body temperature control, by modulating hypothalamic pathways. It is also implicated in feeding behavior and satiety regulation, as it interacts with neuroendocrine circuits that suppress appetite. Beyond the CNS, NMBR influences smooth muscle contraction in the gastrointestinal tract, supporting motility and digestion processes. Its expression in the lungs contributes to pulmonary regulation, including bronchial smooth muscle contraction. Dysregulation of NMBR signaling has been linked to certain neurological disorders and cancer progression, especially in lung and prostate cancers, where it stimulates cell proliferation and migration. NMBR also modulates hormone secretion, including pituitary hormone release, further linking it to neuroendocrine functions. The receptor is currently being explored as a potential therapeutic target for disorders related to appetite regulation, obesity, and specific cancers, given its involvement in growth signaling pathways and cell division.
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