Neuromedin-B Receptor (NMBR) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Neuromedin-B Receptor (NMBR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029084
tested applications
ELISA, WB
Description
Neuromedin-B Receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuromedin-B Receptor (NMBR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P28336 |
| Gene ID | 4829 |
| OMIM | 162341 |
| Alias | NMBR,BB1 receptor,NMB-R BB1,neuromedin B receptor,neuromedin-B-preferring bombesin receptor,BB1R,BRS1 |
| Background | Antibody anti-NMBR |
| Status | RUO |
Descripción
The Neuromedin B receptor (NMBR) is a G-protein-coupled receptor (GPCR) that binds to neuromedin B (NMB), a peptide belonging to the bombesin-like peptide family. NMBR is widely expressed in the central nervous system (CNS), the gastrointestinal tract, and the lungs. In the CNS, NMBR plays a role in thermoregulation, particularly in body temperature control, by modulating hypothalamic pathways. It is also implicated in feeding behavior and satiety regulation, as it interacts with neuroendocrine circuits that suppress appetite. Beyond the CNS, NMBR influences smooth muscle contraction in the gastrointestinal tract, supporting motility and digestion processes. Its expression in the lungs contributes to pulmonary regulation, including bronchial smooth muscle contraction. Dysregulation of NMBR signaling has been linked to certain neurological disorders and cancer progression, especially in lung and prostate cancers, where it stimulates cell proliferation and migration. NMBR also modulates hormone secretion, including pituitary hormone release, further linking it to neuroendocrine functions. The receptor is currently being explored as a potential therapeutic target for disorders related to appetite regulation, obesity, and specific cancers, given its involvement in growth signaling pathways and cell division.
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Neuromedin-B Receptor (NMBR) Antibody
Neuromedin-B Receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.
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