Neprilysin / NEP (MME) Antibody

Descripción

CD10 (MME): membrane metallo-endopeptidase.This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL).This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL.This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues.It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb.The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.The coding region is not affected by alternative splicing.