Neprilysin / NEP (MME) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Neprilysin / NEP (MME) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004332
tested applications
ELISA, WB, IHC
Description
MME Antibody is a Rabbit Polyclonal antibody against MME. This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neprilysin / NEP (MME) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/100 - 1/500, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08473 |
| Gene ID | 4311 |
| NCBI Accession | NP_000893.2 |
| Alias | NEP,SFE,CD10; CALLA,CMT2T,SCA43,Atriopeptidase,Enkephalinase,Neutral endopeptidase,Skin fibroblast elastase |
| Background | Antibody anti-MME |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
MME, also known as neprilysin (NEP) or CD10, is a zinc-dependent metalloprotease enzyme that plays a critical role in various physiological processes, particularly through the degradation of small peptides. Neprilysin is most commonly found on the cell surfaces of various tissues, including the kidneys, lungs, intestines, and the central nervous system. Its primary function involves regulating the levels of biologically active peptides by catalyzing their breakdown, thus influencing many biological systems, including cardiovascular and renal function, pain sensation, and immune responses. Neprilysin is particularly significant in the context of cardiovascular diseases, especially in the metabolism of natriuretic peptides such as atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), both of which play crucial roles in regulating blood pressure and fluid balance. It also degrades neuropeptides like substance P and bradykinin, as well as amyloid-beta peptides in the brain, thus connecting neprilysin to pathologies such as hypertension, heart failure, and Alzheimer's disease.
Related Products
APC Anti-Human CD10(HI10a)
Ver Producto
Human MME (Neprilysin) ELISA Kit
Ver Producto