Neprilysin / NEP (MME) Antibody
221€ (50 µg)
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Name
Neprilysin / NEP (MME) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx159611
Tested Applications
ELISA, IHC
Description
MME Antibody is a Mouse Monoclonal against MME.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neprilysin / NEP (MME) Immunogen: Synthetic Peptide. |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08473 |
| Alias | NEP,SFE,CD10; CALLA,CMT2T,SCA43,Atriopeptidase,Enkephalinase,Neutral endopeptidase,Skin fibroblast elastase |
| Background | Antibody anti-MME |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
MME, also known as neprilysin (NEP) or CD10, is a zinc-dependent metalloprotease enzyme that plays a critical role in various physiological processes, particularly through the degradation of small peptides. Neprilysin is most commonly found on the cell surfaces of various tissues, including the kidneys, lungs, intestines, and the central nervous system. Its primary function involves regulating the levels of biologically active peptides by catalyzing their breakdown, thus influencing many biological systems, including cardiovascular and renal function, pain sensation, and immune responses. Neprilysin is particularly significant in the context of cardiovascular diseases, especially in the metabolism of natriuretic peptides such as atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), both of which play crucial roles in regulating blood pressure and fluid balance. It also degrades neuropeptides like substance P and bradykinin, as well as amyloid-beta peptides in the brain, thus connecting neprilysin to pathologies such as hypertension, heart failure, and Alzheimer's disease.
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