Neogenin 1 (NEO1) Antibody
292.5€ (80 µl)
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Name
Neogenin 1 (NEO1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx029791
Tested Applications
ELISA, WB
Description
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neogenin 1 (NEO1) Immunogen: KLH-conjugated synthetic peptide between 657-685 amino acids from the Central region of human NEO1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 160 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92859 |
| Alias | NGN,IGDCC2,NTN1R2, Immunoglobulin superfamily DCC subclass member 2 |
| Background | Antibody anti-NEO1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Neogenin 1 (NEO1) is a multifunctional transmembrane receptor protein encoded by the NEO1 gene, located on chromosome 15q22.31. It belongs to the immunoglobulin superfamily and is closely related to the Netrin receptors, particularly the Deleted in Colorectal Cancer (DCC) protein. Neogenin 1 plays a pivotal role in a variety of biological processes, including axon guidance, cell migration, apoptosis, and tissue development. Originally identified in neural tissues, NEO1 is now known to be expressed in multiple tissues, indicating its broad biological significance. The receptor is involved in crucial signaling pathways that dictate cell fate and organization during embryonic development and in the adult organism.
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