Family main features
Neogenin 1 (NEO1) is a multifunctional transmembrane receptor protein encoded by the NEO1 gene, located on chromosome 15q22.31. It belongs to the immunoglobulin superfamily and is closely related to the Netrin receptors, particularly the Deleted in Colorectal Cancer (DCC) protein. Neogenin 1 plays a pivotal role in a variety of biological processes, including axon guidance, cell migration, apoptosis, and tissue development. Originally identified in neural tissues, NEO1 is now known to be expressed in multiple tissues, indicating its broad biological significance. The receptor is involved in crucial signaling pathways that dictate cell fate and organization during embryonic development and in the adult organism.
The Neogenin 1 protein consists of several key structural features:
NEO1 is classified as a member of the immunoglobulin superfamily and is closely related to the DCC protein family. Within its classification, NEO1 is distinguished by its ability to interact with both attractive and repulsive guidance cues, a unique feature compared to other family members.
Neogenin 1 is implicated in several critical biological functions:
The diverse functions of NEO1 implicate it in several clinical conditions:
Neogenin 1 (NEO1) is a versatile receptor protein that plays essential roles in neural development, tissue morphogenesis, and cellular homeostasis. Structurally, it features multiple Ig-like and FNIII domains, a transmembrane region, and an intracellular domain with signaling capacity. Functionally, NEO1 mediates axon guidance, cell migration, apoptosis, and tissue development by interacting with Netrins and RGMs. Clinically, NEO1's expression and function are implicated in cancer, neurodevelopmental disorders, and potentially bone and muscle diseases. Understanding NEO1's diverse roles in cellular processes and disease states highlights its significance in both basic biology and clinical research.
neogenin 1 (NEO1)
NGN,IGDCC2,NTN1R2, Immunoglobulin superfamily DCC subclass member 2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits, CLIA Kits) relacionados con NEO1 - neogenin 1
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 15 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | NEO1 | EH1782 | Human NEO1(Neogenin) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q92859 | RUO | ||
Abbexa | NEO1 | abx251089 | Human Neogenin 1 (NEO1) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | 46.9 pg/ml | 525 | 96 tests | RUO | |
Abbexa | NEO1 | abx495995 | Human Neogenin 1 (NEO1) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.063 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | NEO1 | abx152472 | Human Neogenin 1 (NEO1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | NEO1 | abx353330 | Mouse Neogenin 1 (NEO1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 587.5 | 96 tests | P97798 | RUO |
Abbexa | NEO1 | abx354244 | Rat Neogenin 1 (NEO1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 587.5 | 96 tests | P97603 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NEO1 | abx124224 | Neogenin 1 (NEO1) Antibody | Human | Polyclonal | Rabbit | Neogenin 1 (NEO1) | Unconjugated | WB | 175 | 20 µl | Q92859 | RUO | |
Abbexa | NEO1 | abx313765 | Neogenin 1 (NEO1) Antibody (HRP) | Human | Polyclonal | Rabbit | Neogenin 1 (NEO1) | HRP | ELISA | 162.5 | 20 µg | Q92859 | RUO | |
Abbexa | NEO1 | abx313767 | Neogenin 1 (NEO1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Neogenin 1 (NEO1) | Biotin | ELISA | 162.5 | 20 µg | Q92859 | RUO | |
Abbexa | NEO1 | abx177723 | Neogenin 1 (NEO1) Antibody | Human | Polyclonal | Rabbit | Neogenin 1 (NEO1) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO | ||
Abbexa | NEO1 | abx313766 | Neogenin 1 (NEO1) Antibody (FITC) | Human | Polyclonal | Rabbit | Neogenin 1 (NEO1) | FITC | 162.5 | 20 µg | Q92859 | RUO | ||
Abbexa | NEO1 | abx173731 | Neogenin 1 (NEO1) Antibody | Human | Monoclonal | Mouse | Neogenin 1 (NEO1) | Unconjugated | WB, IHC, IF/ICC | 875 | 1 ml | RUO | ||
Abbexa | NEO1 | abx313764 | Neogenin 1 (NEO1) Antibody | Human | Polyclonal | Rabbit | Neogenin 1 (NEO1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q92859 | RUO | |
Abbexa | NEO1 | abx029791 | Neogenin 1 (NEO1) Antibody | Human | Polyclonal | Rabbit | Neogenin 1 (NEO1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q92859 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | NEO1 | abx654484 | Human Neogenin 1 (NEO1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | Q92859 | RUO |
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