MRGPRX3 Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
MRGPRX3 Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx310059
Description
MRGPRX3 Antibody (FITC) is a Rabbit Polyclonal against MRGPRX3 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | MRGPRX3 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96LB0 |
| Gene ID | 117195 |
| OMIM | 607229 |
| Alias | MRGPRX3,MrgA,Mrgpra,Mrga10,SNSR1,Sensory neuron-specific G protein-coupled receptor 1,GPCR,MRGX3,SNSR1,SNSR2 |
| Background | Antibody anti-MRGPRX3 |
| Status | RUO |
Descripción
MRGPRX3 is a member of the MAS-related GPR family of receptors, similar in structure and function to MRGPRX1 and MRGPRX2. It is expressed in sensory neurons and mast cells, playing a role in the mediation of allergic responses and pain. MRGPRX3 is activated by various endogenous peptides and is involved in the release of histamine and other mediators from mast cells, contributing to allergic inflammation. It is particularly involved in the sensation of itch and may also play a role in modulating pain sensitivity and neurogenic inflammation. The receptor’s activation leads to the initiation of intracellular signaling cascades that include calcium release and other pro-inflammatory responses. Dysregulation of MRGPRX3 signaling is linked to disorders involving chronic pain, itch, and hypersensitivity. As a potential therapeutic target, MRGPRX3 could be modulated for the treatment of chronic pain conditions, allergic disorders, and inflammatory diseases.
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