Mouse Transcription factor E2F2 (E2F2) ELISA Kit
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Mouse Transcription factor E2F2 (E2F2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transcription factor E2F2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transcription factor E2F2 (E2F2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P56931 |
| Gene ID | 242705 |
| Alias | E2F-2 |
| Background | Elisa kits for E2F2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
E2F2 is another member of the E2F family that functions as a key transcriptional regulator of genes involved in cell cycle progression, particularly during the G1/S transition. Like E2F1, E2F2 is regulated by the retinoblastoma protein (pRB), which controls its ability to activate target genes necessary for DNA replication and mitosis. E2F2 plays a role in balancing cell proliferation and differentiation, particularly in hematopoietic and immune cells. Dysregulation of E2F2 contributes to hyperproliferation, genomic instability, and tumorigenesis, with studies showing its overexpression in cancers such as lymphoma and leukemia. Conversely, E2F2 can act as a tumor suppressor in specific contexts by inducing cell cycle arrest or apoptosis. Knockout models exhibit impaired T cell differentiation, deregulated cell growth, and altered immune homeostasis, highlighting E2F2’s role in cell cycle regulation, immune development, and cancer biology.
Related Products
E2F Transcription Factor 2 (E2F2) Antibody
Rabbit polyclonal antibody against E2F2 protein. Immunogen region is Internal.
Ver Producto
E2F Transcription Factor 2 (E2F2) Antibody
E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq].
Ver Producto
E2F Transcription Factor 2 (E2F2) Antibody
E2F Transcription Factor 2 Antibody is a Rabbit Polyclonal against E2F Transcription Factor 2.
Ver Producto