E2F Transcription Factor 2 (E2F2) Antibody
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Description
Rabbit polyclonal antibody against E2F2 protein. Immunogen region is Internal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | E2F Transcription Factor 2 (E2F2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14209 |
| Alias | E2F-2 |
| Background | Antibody anti-E2F2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
E2F2 is another member of the E2F family that functions as a key transcriptional regulator of genes involved in cell cycle progression, particularly during the G1/S transition. Like E2F1, E2F2 is regulated by the retinoblastoma protein (pRB), which controls its ability to activate target genes necessary for DNA replication and mitosis. E2F2 plays a role in balancing cell proliferation and differentiation, particularly in hematopoietic and immune cells. Dysregulation of E2F2 contributes to hyperproliferation, genomic instability, and tumorigenesis, with studies showing its overexpression in cancers such as lymphoma and leukemia. Conversely, E2F2 can act as a tumor suppressor in specific contexts by inducing cell cycle arrest or apoptosis. Knockout models exhibit impaired T cell differentiation, deregulated cell growth, and altered immune homeostasis, highlighting E2F2’s role in cell cycle regulation, immune development, and cancer biology.
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