Mouse Signal Transducing Adaptor Protein 1 (STAP1) Protein
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Description
Recombinant Signal Transducing Adaptor Protein 1 (STAP1) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Signal Transducing Adaptor Protein 1 (STAP1) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 38.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ala297 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9JM90 |
| Alias | STAP1,BRDG1, STAP-1, signal transducing adaptor family member 1 |
| Background | Protein STAP1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
STAP1 is an SH2 domain-containing adaptor protein that regulates cytokine receptor and tyrosine kinase signaling pathways. It interacts with proteins like c-Kit and Jak kinases to mediate downstream activation of signaling cascades such as MAPK, PI3K/Akt, and STAT pathways, influencing cellular proliferation, survival, and differentiation. STAP1 is expressed in hematopoietic and immune cells, where it modulates cytokine responses, immune cell activation, and differentiation. Dysregulation of STAP1 has been linked to immune dysfunction, leukemia, and certain inflammatory disorders due to its role in promoting cytokine-mediated signaling and hematopoietic regulation. Knockdown studies demonstrate impaired cytokine signaling, reduced proliferation, and abnormal immune responses, highlighting its role in fine-tuning signaling pathways during immune regulation and hematopoiesis.
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