Mouse Receptor-type tyrosine-protein phosphatase T (PTPRT) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits PTPRT
proveedor
Abbexareference
abx390423Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Receptor-type tyrosine-protein phosphatase T (PTPRT) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse PTPRT concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
PTPRT is a receptor-type protein tyrosine phosphatase critical for cell adhesion, neuronal development, and tumor suppression. Structurally, PTPRT features extracellular immunoglobulin (Ig)-like and fibronectin type III domains, a transmembrane domain, and two intracellular phosphatase domains, one of which is catalytically active. PTPRT is predominantly expressed in the central nervous system, particularly in neurons, where it regulates synaptic formation and maintenance. It interacts with cadherins and β-catenin to control cell-cell adhesion and neuronal connectivity. PTPRT acts as a tumor suppressor by dephosphorylating STAT3, a transcription factor involved in promoting cell survival and proliferation. Mutations or inactivation of PTPRT have been identified in colorectal, lung, and gastric cancers, linking its dysregulation to tumorigenesis. PTPRT’s role in synaptic plasticity and cancer highlights its dual significance in neurological and oncogenic processes, making it a target for therapeutic intervention.
Características del producto
category
ELISA Kits
immunogen target
Receptor-type tyrosine-protein phosphatase T (PTPRT)
reactivity
Mouse
test range
78 pg/ml - 5000 pg/ml
sensitivity
< 46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
R-PTP-T,RPTPrho,RPTP-rho,Receptor-type tyrosine-protein phosphatase rho,R-PTP-T,Receptor-type tyrosine-protein phosphatase T
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
PTPRT
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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