Mouse P2Y Purinoceptor 12 (P2RY12) ELISA Kit

Este producto es parte de P2RY  - Purinergic Receptor P2Y
Mouse P2Y Purinoceptor 12 (P2RY12) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for P2RY12

proveedor

Abbexa

reference

abx515936

Tested Applications

ELISA

reactivity

Mouse

status

RUO

clonality

Descripción

Mouse Purinergic Receptor P2Y12 (P2RY12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse P2Y purinoceptor 12 concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

P2RY12 is a G protein-coupled receptor activated by ADP, playing a crucial role in platelet aggregation and thrombus formation. P2RY12 couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and enhancing platelet activation and aggregation in response to ADP. It is highly expressed in platelets and some immune cells, where it regulates hemostasis, inflammation, and thrombosis. P2RY12 is a major target for antiplatelet drugs such as clopidogrel, prasugrel, and ticagrelor, which are used to prevent arterial thrombosis, stroke, and myocardial infarction by inhibiting platelet activation. Dysregulation of P2RY12 contributes to thrombotic disorders, while excessive inhibition can lead to bleeding complications. Beyond its role in hemostasis, P2RY12 is involved in immune cell chemotaxis and inflammatory responses. The therapeutic targeting of P2RY12 continues to evolve, particularly for the management of cardiovascular diseases, thrombosis, and inflammation.

Características del producto

category

ELISA Kits


immunogen target

P2Y Purinoceptor 12 (P2RY12)


reactivity

Mouse


test range

0.156 ng/ml - 10 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

P2RY12,SP1999,P2YADP,HORK3,P2Y purinoceptor 12,P2Y12 platelet ADP receptor,purinergic receptor P2Y,ADPG-R,BDPLT8,HORK3,P2T(AC),P2Y(12)R,P2Y(AC),P2Y(ADP),P2Y(cyc),P2Y12


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

P2RY12


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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reactivity

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status

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