Mouse Protein tilB homolog (LRRC6) ELISA Kit
715€ (96 tests)
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name
Mouse Protein tilB homolog (LRRC6) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx549720
tested applications
ELISA
Description
Mouse Protein tilB homolog (LRRC6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Protein tilB homolog concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Protein tilB homolog (LRRC6) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O88978 |
| Gene ID | 54562 |
| Alias | LRRC6,Leucine-rich testis-specific protein,Protein tilB homolog |
| Background | Elisa kits for DNAAF11 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DNAAF11, also known as LRRC6, is a dynein axonemal assembly factor essential for the preassembly and transport of axonemal dynein arms into motile cilia. It interacts with chaperone proteins and cytoplasmic complexes to facilitate the proper folding, assembly, and localization of dynein motor components, ensuring the beating of motile cilia and flagella. DNAAF11 is expressed in ciliated tissues, including the respiratory tract, reproductive organs, and brain ependyma, where it regulates processes like mucus clearance, sperm motility, and cerebrospinal fluid flow. Mutations in DNAAF11 result in primary ciliary dyskinesia (PCD), a disorder characterized by immotile or dyskinetic cilia, leading to chronic respiratory infections, infertility, and hydrocephalus. Functional studies reveal that DNAAF11 deficiency disrupts dynein arm assembly, causing structural defects in cilia and impaired motility, underscoring its essential role in axonemal dynein regulation, ciliary function, and human health.
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