Human Protein tilB homolog (LRRC6) ELISA Kit

Name: Human Protein tilB homolog (LRRC6) ELISA Kit
Brand: Abbexa
SKU: abx549719
Price: 715 EUR
Availability: OnlineOnly

Este producto es parte de LRRC - Leucine-rich repeat-containing protein

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for DNAAF11

proveedor

Abbexa

reference

abx549719

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Protein tilB homolog (LRRC6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Protein tilB homolog (LRRC6) concentrations in tissue homogenates, cell lysates and other biological fluids.

Background

DNAAF11, also known as LRRC6, is a dynein axonemal assembly factor essential for the preassembly and transport of axonemal dynein arms into motile cilia. It interacts with chaperone proteins and cytoplasmic complexes to facilitate the proper folding, assembly, and localization of dynein motor components, ensuring the beating of motile cilia and flagella. DNAAF11 is expressed in ciliated tissues, including the respiratory tract, reproductive organs, and brain ependyma, where it regulates processes like mucus clearance, sperm motility, and cerebrospinal fluid flow. Mutations in DNAAF11 result in primary ciliary dyskinesia (PCD), a disorder characterized by immotile or dyskinetic cilia, leading to chronic respiratory infections, infertility, and hydrocephalus. Functional studies reveal that DNAAF11 deficiency disrupts dynein arm assembly, causing structural defects in cilia and impaired motility, underscoring its essential role in axonemal dynein regulation, ciliary function, and human health.

Características del producto

immunogen target

Protein tilB homolog (LRRC6)

reactivity

Human

test range

0.156 ng/ml - 10 ng/ml

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Tissue homogenates, cell lysates and other biological fluids.

size 1

96 tests

alias

LRRC6,Leucine-rich testis-specific protein,Protein tilB homolog

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

DNAAF11

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q86X45

gene id

https://www.ncbi.nlm.nih.gov/gene/23639

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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Leucine-Rich Repeat-Containing Protein 6 (LRRC6) Antibody

proveedor

Abbexa

reference

abx026421

Tested Applications

ELISA, WB, FCM

reactivity

Human

status

RUO

clonality

Polyclonal

LRRC6 may be involved in spermatocytogenesis or prophase of meiosis (By similarity).

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