Leucine-Rich Repeat-Containing Protein 6 (LRRC6) Antibody

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 6 (LRRC6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026421
tested applications
ELISA, WB, FCM

Description

LRRC6 may be involved in spermatocytogenesis or prophase of meiosis (By similarity).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Leucine-Rich Repeat-Containing Protein 6 (LRRC6)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB, FCM
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q86X45
Alias
LRRC6,Leucine-rich testis-specific protein,Protein tilB homolog
Background
Antibody anti-DNAAF11
Status
RUO

Descripción

DNAAF11, also known as LRRC6, is a dynein axonemal assembly factor essential for the preassembly and transport of axonemal dynein arms into motile cilia. It interacts with chaperone proteins and cytoplasmic complexes to facilitate the proper folding, assembly, and localization of dynein motor components, ensuring the beating of motile cilia and flagella. DNAAF11 is expressed in ciliated tissues, including the respiratory tract, reproductive organs, and brain ependyma, where it regulates processes like mucus clearance, sperm motility, and cerebrospinal fluid flow. Mutations in DNAAF11 result in primary ciliary dyskinesia (PCD), a disorder characterized by immotile or dyskinetic cilia, leading to chronic respiratory infections, infertility, and hydrocephalus. Functional studies reveal that DNAAF11 deficiency disrupts dynein arm assembly, causing structural defects in cilia and impaired motility, underscoring its essential role in axonemal dynein regulation, ciliary function, and human health.
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