Mouse Free Fatty Acid Receptor 3 (FFAR3) Protein

Este producto es parte de FFAR - Free Fatty Acid Receptor
Mouse Free Fatty Acid Receptor 3 (FFAR3) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein FFAR3

proveedor

Abbexa

reference

abx652085

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse Free Fatty Acid Receptor 3 (FFAR3) Protein is a Recombinant Mouse protein expressed in E. coli.


Background

FFAR3, or GPR41, is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. It is highly expressed in the gastrointestinal tract, adipose tissue, and autonomic nervous system, where it regulates energy metabolism, gut hormone secretion, and immune responses. FFAR3 activation enhances the release of gut peptides like peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), contributing to appetite regulation, insulin sensitivity, and glucose homeostasis. In the autonomic nervous system, FFAR3 modulates sympathetic nervous activity, influencing energy expenditure and blood pressure. Dysregulation of FFAR3 signaling is associated with obesity, type 2 diabetes, and cardiovascular diseases, as impaired SCFA signaling disrupts metabolic balance. FFAR3 also plays a role in immune function by regulating cytokine production and neutrophil activity. As a critical link between gut microbiota and host physiology, FFAR3 is a promising therapeutic target for metabolic diseases, obesity, and cardiovascular disorders.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Free Fatty Acid Receptor 3 (FFAR3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 18.7 kDa Observed MW (SDS-PAGE): 21 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser276-Ser319 Tag: N-terminal His tag and SUMO tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

FFAR3


dry ice

No


availability

Shipped within 5-7 working days.


alias

FFAR3,FFA3R,GPR41,LSSIG,G protein-coupled receptor 41,GPCR41


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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