Mouse Free Fatty Acid Receptor 3 (FFAR3) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein FFAR3
proveedor
Abbexareference
abx652085Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Free Fatty Acid Receptor 3 (FFAR3) Protein is a Recombinant Mouse protein expressed in E. coli.
Background
FFAR3, or GPR41, is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. It is highly expressed in the gastrointestinal tract, adipose tissue, and autonomic nervous system, where it regulates energy metabolism, gut hormone secretion, and immune responses. FFAR3 activation enhances the release of gut peptides like peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), contributing to appetite regulation, insulin sensitivity, and glucose homeostasis. In the autonomic nervous system, FFAR3 modulates sympathetic nervous activity, influencing energy expenditure and blood pressure. Dysregulation of FFAR3 signaling is associated with obesity, type 2 diabetes, and cardiovascular diseases, as impaired SCFA signaling disrupts metabolic balance. FFAR3 also plays a role in immune function by regulating cytokine production and neutrophil activity. As a critical link between gut microbiota and host physiology, FFAR3 is a promising therapeutic target for metabolic diseases, obesity, and cardiovascular disorders.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Free Fatty Acid Receptor 3 (FFAR3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 18.7 kDa Observed MW (SDS-PAGE): 21 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ser276-Ser319 Tag: N-terminal His tag and SUMO tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
FFAR3
dry ice
No
availability
Shipped within 5-7 working days.
alias
FFAR3,FFA3R,GPR41,LSSIG,G protein-coupled receptor 41,GPCR41
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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