Free Fatty Acid Receptor 3 (FFAR3) Antibody
292.5€ (80 µl)
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935106861
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name
Free Fatty Acid Receptor 3 (FFAR3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx032444
tested applications
ELISA, WB, FCM
Description
FFAR3 is receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1, 4, 5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Free Fatty Acid Receptor 3 (FFAR3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14843 |
| NCBI Accession | NP_005295.1 |
| Alias | FFAR3,FFA3R,GPR41,LSSIG,G protein-coupled receptor 41,GPCR41 |
| Background | Antibody anti-FFAR3 |
| Status | RUO |
Descripción
FFAR3, or GPR41, is a G protein-coupled receptor activated by short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. It is highly expressed in the gastrointestinal tract, adipose tissue, and autonomic nervous system, where it regulates energy metabolism, gut hormone secretion, and immune responses. FFAR3 activation enhances the release of gut peptides like peptide YY (PYY) and glucagon-like peptide-1 (GLP-1), contributing to appetite regulation, insulin sensitivity, and glucose homeostasis. In the autonomic nervous system, FFAR3 modulates sympathetic nervous activity, influencing energy expenditure and blood pressure. Dysregulation of FFAR3 signaling is associated with obesity, type 2 diabetes, and cardiovascular diseases, as impaired SCFA signaling disrupts metabolic balance. FFAR3 also plays a role in immune function by regulating cytokine production and neutrophil activity. As a critical link between gut microbiota and host physiology, FFAR3 is a promising therapeutic target for metabolic diseases, obesity, and cardiovascular disorders.
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