Mouse Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides (DAPP1) Protein

Product specifications

Proteins and Peptides

Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides (DAPP1)

E. coli

Mouse

Unconjugated

Molecular Weight: Calculated MW: 36.0 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Lys280
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

Q9QXT1

DAPP1, BAM32,B lymphocyte adapter protein Bam32

Protein DAPP1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

DAPP1 (Dual Adapter for Phosphotyrosine and 3-Phosphoinositide) is a multifunctional adaptor protein involved in the regulation of cellular signaling pathways. It contains both SH2 (Src Homology 2) and PH (Pleckstrin Homology) domains, which allow it to interact with phosphorylated tyrosine residues and phosphoinositides, respectively. These interactions make DAPP1 a key player in the regulation of various cellular processes, including signal transduction, immune responses, and actin cytoskeleton remodeling. DAPP1 is especially important in immune cells, where it participates in the regulation of B cell receptor (BCR) signaling. Upon BCR activation, DAPP1 translocates to the plasma membrane and helps coordinate downstream signaling events that control cell survival, differentiation, and proliferation. It plays a role in modulating cell motility and the immune synapse, contributing to efficient immune responses. DAPP1 is also involved in the regulation of intracellular calcium signaling, which is crucial for processes like cell activation and communication. Its function is tightly regulated, and alterations in DAPP1 expression or activity can lead to immune dysfunction and have been implicated in various diseases, including cancer and autoimmune disorders.

Related Products

DAPP1 antibody

May act as a B-cell-associated adapter that regulates B-cell antigen receptor(BCR)-signaling downstream of PI3K.

Ver Producto

Dual Adaptor of Phosphotyrosine And 3-Phosphoinositides 1 (DAPP1) Antibody

DAPP1 may act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR) signaling downstream of PI3K.

Ver Producto

Dual Adaptor of Phosphotyrosine And 3-Phosphoinositides 1 (DAPP1) Antibody

Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides Antibody is a Rabbit Polyclonal antibody against Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides.

Ver Producto