Dual Adaptor of Phosphotyrosine And 3-Phosphoinositides 1 (DAPP1) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Dual Adaptor of Phosphotyrosine And 3-Phosphoinositides 1 (DAPP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029493
tested applications
ELISA, WB
Description
DAPP1 may act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR) signaling downstream of PI3K.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Dual Adaptor of Phosphotyrosine And 3-Phosphoinositides 1 (DAPP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UN19 |
| Alias | DAPP1, BAM32,B lymphocyte adapter protein Bam32 |
| Background | Antibody anti-DAPP1 |
| Status | RUO |
Descripción
DAPP1 (Dual Adapter for Phosphotyrosine and 3-Phosphoinositide) is a multifunctional adaptor protein involved in the regulation of cellular signaling pathways. It contains both SH2 (Src Homology 2) and PH (Pleckstrin Homology) domains, which allow it to interact with phosphorylated tyrosine residues and phosphoinositides, respectively. These interactions make DAPP1 a key player in the regulation of various cellular processes, including signal transduction, immune responses, and actin cytoskeleton remodeling. DAPP1 is especially important in immune cells, where it participates in the regulation of B cell receptor (BCR) signaling. Upon BCR activation, DAPP1 translocates to the plasma membrane and helps coordinate downstream signaling events that control cell survival, differentiation, and proliferation. It plays a role in modulating cell motility and the immune synapse, contributing to efficient immune responses. DAPP1 is also involved in the regulation of intracellular calcium signaling, which is crucial for processes like cell activation and communication. Its function is tightly regulated, and alterations in DAPP1 expression or activity can lead to immune dysfunction and have been implicated in various diseases, including cancer and autoimmune disorders.
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