anti- DAPP1 antibody
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935106861
info@markelab.com
name
anti- DAPP1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02242
tested applications
ELISA, IHC, IF
Description
May act as a B-cell-associated adapter that regulates B-cell antigen receptor(BCR)-signaling downstream of PI3K.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | dual adaptor of phosphotyrosine and 3-phosphoinositides |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UN19 |
| Gene ID | 27071 |
| Alias | DAPP1, BAM32,B lymphocyte adapter protein Bam32 |
| Background | Antibody anti-DAPP1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
DAPP1 (Dual Adapter for Phosphotyrosine and 3-Phosphoinositide) is a multifunctional adaptor protein involved in the regulation of cellular signaling pathways. It contains both SH2 (Src Homology 2) and PH (Pleckstrin Homology) domains, which allow it to interact with phosphorylated tyrosine residues and phosphoinositides, respectively. These interactions make DAPP1 a key player in the regulation of various cellular processes, including signal transduction, immune responses, and actin cytoskeleton remodeling. DAPP1 is especially important in immune cells, where it participates in the regulation of B cell receptor (BCR) signaling. Upon BCR activation, DAPP1 translocates to the plasma membrane and helps coordinate downstream signaling events that control cell survival, differentiation, and proliferation. It plays a role in modulating cell motility and the immune synapse, contributing to efficient immune responses. DAPP1 is also involved in the regulation of intracellular calcium signaling, which is crucial for processes like cell activation and communication. Its function is tightly regulated, and alterations in DAPP1 expression or activity can lead to immune dysfunction and have been implicated in various diseases, including cancer and autoimmune disorders.
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