Mouse Contactin 3 (CNTN3) Protein
234€ (10 µg)
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name
Mouse Contactin 3 (CNTN3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx066111
tested applications
WB, SDS-PAGE
Description
Mouse Contactin 3 (CNTN3) is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Contactin 3 (CNTN3) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser264-His493 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 29.6 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q07409 |
| Alias | PCS,PANG,BIG-1,KIAA1496,Plasmacytoma-associated neuronal glycoprotein,Brain-derived immunoglobulin superfamily protein 1,Contactin-3 |
| Background | Protein CNTN3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Contactin 3 (CNTN3), also known as BIG-1, is a neural adhesion molecule that belongs to the contactin family and is primarily expressed in the brain, particularly in areas involved in learning and memory, such as the hippocampus and cortex. CNTN3 mediates cell-cell adhesion and axonal interactions, contributing to synaptic formation and plasticity. It interacts with other neuronal receptors and adhesion molecules to regulate axon guidance and neuronal migration during development. CNTN3 has been implicated in neurodevelopmental disorders, including autism spectrum disorders and schizophrenia, where its dysregulation disrupts synaptic connectivity and neural circuit function. Its expression is developmentally regulated, with high levels observed during embryonic and early postnatal stages. Structurally, CNTN3 features immunoglobulin and fibronectin type III domains, facilitating homophilic and heterophilic interactions that are essential for its role in neural development. Emerging research suggests that CNTN3 may also have a role in neurodegenerative diseases and brain plasticity, though its exact mechanisms remain under investigation.
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